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Skin damage from UV light seen in sun-shielded skin

PLOS Genetics
Reuters Health - 18/01/2021 - UV light-related skin damage is common even in skin cells typically shielded from the sun, regardless of a person's age, whereas endogenous DNA skin damage - from metabolic byproducts - accumulates over time, a sequencing study reveals. "Baseline levels of genome changes in skin defined by our study will help us and other researchers to identify gene variants resulting in higher, potentially disease-prone levels of genome instability in individuals recruited from the NIEHS Environmental Polymorphisms Registry (EPR; https://bit.ly/2KqkqU6), " Dr. Dmitry Gordenin of the U.S. National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina told Reuters Health by email. "Ongoing whole-genome sequencing of thousands of EPR DNAs," he said, "will allow us to limit recruitment and somatic clone sequencing to individuals that carry variants of unknow...

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