Secukinumab: a new management option for paediatric severe psoriasis

A new option for the management of paediatric severe chronic plaque psoriasis has just emerged with the approval of secukinumab by the European Commission (EC) for the treatment of paediatric moderate-to-severe chronic plaque psoriasis [1]. Until now, there have been limited treatment options for this condition; off-label regimens are frequently utilised with suboptimal results. Secukinumab is a fully human monoclonal antibody that inhibits interleukin (IL)-17, thus disrupting one of the key cytokines involved in the inflammatory pathway which leads to the formation of psoriatic plaques. Prof. Christine Bodemer (Necker–Enfants Malades Hospital, France) reviewed the results to date of a phase 3, randomised, double-blind trial at the EADV Virtual Congress [2]. The 162 subjects between the age of 6 and 18 were randomised to 1 of 4 treatment arms: low-dose secukinumab, high-dose secukinumab, ...

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Posted on 2 November, 202018 December, 2020