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Statin use tied to better outcomes in men with prostate cancer starting androgen-deprivation therapy

Journal
European Urology
Reuters Health - 07/01/2021 - Statin therapy is associated with improved outcomes in men initiating androgen-deprivation therapy (ADT) for prostate cancer, new research suggests. "Interest in statins as a potential chemopreventive agent has grown, and there exist biological rationale, and laboratory and clinical data supporting our findings," the study team writes in European Urology. Observational studies examining statin use and prostate-cancer risk have shown a modest but statistically significant overall risk reduction and a more clinically meaningful reduction in advanced or high-grade disease. But whether statin use at the time of primary treatment is associated with improved outcomes remains unclear, they point out. To evaluate the association between statin use and outcomes, Dr. Robert Hamilton with Princess Margaret Cancer Center in Toronto, Canada, and colleagues did a post hoc secondary analysis of a randomized controlled trial of men initiating in...


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