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For COPD with nocturnal hypoxemia, nighttime oxygen has no survival benefit

Journal
New England Journal of Medicine
Reuters Health - 16/09/2020 - Although long-term oxygen therapy helps people with chronic obstructive pulmonary disease and chronic severe daytime hypoxemia live longer, it does not appear to improve survival in people with isolated nocturnal hypoxemia, according to a test of the common treatment. After three years of follow-up, 39.0% for the 123 people randomly assigned to nocturnal oxygen needed long-term oxygen therapy or had died versus 42.0% for the 119 who received their nighttime air from a sham concentrator, a non-significant difference, researchers report in the New England Journal of Medicine. In addition, "Nocturnal oxygen had no observed effect on secondary outcomes, including exacerbation and hospitalization rates and quality of life," the researchers write. "Furthermore, the duration of exposure to nocturnal oxygen did not modify the overall effect of therapy." However, the trial, known as INOX, was underpowered. The research team had expected t...


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