European Respiratory Society International Congress (ERS 2023), held in 9-13 September 2023 in Milan, Italy. The topics discussed are:
- Eosinophilic asthma: Most patients on benralizumab can successfully taper inhaled corticosteroids
After 32 weeks, a reduction of high-dose inhaled corticosteroids/formoterol (HD ICS/F) was possible in 92% of patients, who had been stable on benralizumab. This lower dosage was maintained to week 48 by 95.8%. - Maturation of the gut microbiome protects against allergic manifestations in early childhood
Babies and infants with a mature gut microbiome are less likely to develop allergy-related wheezing and asthma in early childhood. This showed a subgroup analysis including 323 babies of the Australian Barwon Infant study. - Pulmonary fibrosis: a new treatment on the horizon?
BMS-986278 reduced percent predicted (pp) FVC decline in patients with progressive pulmonary fibrosis (PPF). Results were similar between groups with or without background therapy. - Sotatercept: Promising long-term results in PAH treatment
Extended sotatercept as an add-on treatment for pulmonary arterial hypertension (PAH), showed sustained maintenance of benefit in a long-term open-label extension. The safety assessment indicated low treatment-related discontinuation. - Idrevloride augments pulmonary function in patients with primary ciliary dyskinesia
The treatment of primary ciliary dyskinesia (PCD) patients with a combination of idrevloride and hypertonic saline (HS) resulted in significant improvement of percent predicted (pp) FEV1 compared with saline alone or placebo after 1 month. The treatment did not lead to evidence of hyperkalemia. - Possible treatment targets to reduce fatigue in COPD patients discovered
New data found that higher pain levels and poor sleep quality were among the factors that significantly influenced the intensity of fatigue. Other relevant factors were shortness of breath and fatigue-catastrophising.
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Table of Contents: ERS 2023
Featured articles
Letter from the Editor
Best of the Posters
sRAGE: A novel potential biomarker to assess the risk of acute respiratory events
Most severe asthma patients are candidates for biologic therapy on a global scale
Aspergillus infections: resistance to azole treatment increased in the presence of diesel particles
Asthma in 2023
Tapering from high-dose inhaled corticosteroids possible in most asthma patients treated with benralizumab
Tezepelumab therapy: hints toward a disease-modifying effect?
Digital inhaler programme improves asthma control also in the long term, but not long-term adherence
Respiratory health in children
Large infant study demonstrates the importance of a mature microbiome
Healthy maternal lifestyle during pregnancy reduces wheezing and rhinitis in infants
Mechanism of autophagy in a newborn responsible for deleterious effect of air pollutants
COPD: New Developments
Gabapentinoids increase risk of exacerbations in COPD
Future treatment of fatigue in COPD: 4 possible targets identified
Pulmonary Consequences of Long COVID
Women at higher risk of functional respiratory complaints following a COVID-19 infection
Elevated myeloid inflammation and complement activation present in various phenotypes of long COVID
Pulmonary Arterial Hypertension (PAH): Novel Developments
Encouraging long-term outcomes observed in the treatment of PAH with sotatercept
Chronic thromboembolic pulmonary hypertension: surgery entails encouraging long-term results
Women with pulmonary hypertension have better survival chances than men
Rare Diseases in 2023
Primary ciliary dyskinesia: Idrevloride shows promising results in phase 2 trial
Promising new agent as treatment for pulmonary fibrosis
Novel immunomodulator offers hope to reduce steroid dependency in sarcoidosis
Other Research of Interest
Tacrolimus versus cyclosporin: Less lung graft dysfunction
CPAP effective in reducing cardiovascular mortality in a practice study
Gefapixant curbs chronic cough independent of its duration
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