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Aerosolized surfactant shows promise for newborns with respiratory distress

Journal
Pediatrics
Reuters Health - 15/10/2020 - Delivery of aerosolized calfactant, a type of surfactant, reduced the need for intubation for liquid surfactant by nearly 50% in a large randomized controlled trial of newborns with respiratory distress syndrome (RDS). "As a result, far fewer infants in the aerosol group were subjected to the potential harms of laryngoscopy and intubation," Dr. James Cummings from Albany Medical College in New York and the AERO-02 study team reports in a paper in Pediatrics today. They note that currently, exogenous surfactants for RDS are approved for tracheal instillation only, which requires intubation, often followed by positive pressure ventilation to promote distribution. Aerosol delivery offers a safer alternative, but clinical studies have yielded mixed results. The new study enrolled 457 newborns (median gestation, 33 weeks; median birth weight, 1960 grams) with signs of mild to moderate RDS requiring noninvasive respiratory support; 230...


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