Sentinel-lymph-node biopsy has edge on lymphadenectomy in endometrial-cancer staging

Reuters Health - 19/11/2020 - In patients with high-grade endometrial cancer, sentinel-lymph-node biopsy (SLNB) has a diagnostic accuracy comparable to that of lymphadenectomy and shows enhanced detection of node-positive disease, according to a prospective study. SLNB has been proposed as a less invasive strategy for nodal assessment, but whether it can reliably replace lymphadenectomy is unclear, Dr. Sarah E. Ferguson of University Health Network/Sinai Health Systems in Toronto, Canada, and colleagues write in JAMA Surgery. The researchers studied 156 patients (median age, 65.5 years) with endometrial cancer, of whom 126 (81%) had high-grade disease. All underwent SLNB followed by the reference standard pelvic lymphadenectomy (PLND). In addition, 101 of the patients with high-grade disease also underwent para-aortic lymphadenectomy (PALND). SLN detection rates were 97.4% per patient, 87.5% per hemipelvis and 77.6% bilaterally. Of the 27 patients (17%) with ...

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Posted on 19 November, 202026 November, 2020