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Radiotherapy for rectal cancer linked to risk for later malignant gynecological neoplasms

Journal
JAMA Network Open
Reuters Health - 08/01/2021 - Women who receive radiotherapy for rectal cancer may be at an increased risk of uterine and ovarian cancer, a new study suggests. In an analysis of information from the SEER database on more than 20,000 female patients diagnosed with rectal cancer, researchers found the treatment was associated with a three-fold increased risk of subsequent uterine cancer and a two-fold increased risk of ovarian cancer, according to the report published in JAMA Network Open. "In our analysis, we assessed the dynamic risk and incidence of SGMN (second gynecological malignant neoplasms)," write the authors, led Xu Guan of the National Center/Cancer Hospital, Chinese Academy of Sciences and Peking Union Medical College in Beijing. "The highest radiotherapy-associated risk for developing ovarian cancer was found after a latency of more than 20 years, but for cancer of the uterine corpus, the highest risk was found within five to 10 years," they write...


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