Welcome to Medicom's report of this year's ESMO Annual Congress!
Again, as in previous years: quite some practice changing studies.
Remarkably, in the field of ovarian cancer, there are three parallel studies providing evidence for clinically relevant benefit of targeted agents (PARP inhibitors) – as well as the predictive factors: BRCA as an already established – and HRD, a “BRCA-ness” predictive factor well established through the 3 studies, broadening the patient group identifiable as the most benefitting.
Read the exciting results presented by Julien Taieb: are we getting closer to a true predictive marker in stage II colorectal cancer in detecting circulating tumor DNA after primary surgery? Can we stratify adjuvant treatment according to ctDNA?
Will we eventually treat all our patients with advanced non-small cell lung cancer without chemotherapy?
…just some examples. I'll stop here and let you have a closer look at our report.
Medical Oncology – truly evolving!
Yours, sincerely
Stefan Rauh
Biography
Dr Stefan Rauh is currently working as haemato-oncologist in the oncology department of Centre Hospitalier Emile Mayrisch, Esch, Luxembourg. He is mainly involved in clinical work but also in research and teaching activities and is interested in public policy and international cooperation projects in oncology. He is Chair of the ESMO Practicing Oncologist’s Working Group since 2015, member of the ESMO Quality Task Force, extended member of the ESMO Public Policy Committee, Assistant Editor of ESMO Cancer Horizons, and has been an ESMO Executive Board member in 2015-2016. He is co-author of the 2017 ESMO European Cancer Patient Coalition (ECPC) Patient Survivorship Guide and an invited expert for the ECPC.
Conflict of Interest Statement: Nothing to declare
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Table of Contents: ESMO 2019
Featured articles
Interview with ESMO President Prof. Josep Tabernero
Breast Cancer
Triple negative breast cancer gets positive news: KEYNOTE-522 interim results
CDK4/6 inhibitors change landscape of breast cancer treatment: 2 studies
Veliparib-chemo combo prolongs survival without disease progression in some advanced breast cancer patients
Lung Cancer
Improved response rates without survival benefit with pembrolizumab in pretreated mesothelioma
Frontline ipilimumab/nivolumab improves OS in advanced NCLSC
First-line osimertinib significantly lengthens OS in NSCLC
Liquid biopsy to decide the best treatment for NSCLC
Melanoma
Long-term data from CheckMate 067
Adjuvant nivolumab provides benefit
Nivolumab+ipilimumab superior to monotherapy for melanoma brain metastases
GI Cancers
Preoperative chemotherapy for colon cancer
Nivolumab improves OS in advanced oesophageal cancer
Liquid biopsy identifies relapse in patients with colorectal cancer after surgery
In hepatocellular carcinoma, CheckMate 459 misses OS endpoint, but some interesting trends emerge
Heavily pre-treated GIST: ripretinib improves PFS
FGFR2+ cholangiocarcinoma: pemigatinib active as second-line treatment
IDH1+ cholangiocarcinoma: phase 3 results show improved PFS
Advanced colorectal cancer and BRAF mutations: triplet combination improves survival
Genitourinary Cancers
25% reduction in the risk of death in patients with nmCRPC treated with apalutamide
Enfortumab vedotin and pembrolizumab in advanced bladder cancer: initial results
PARP inhibition in selected patients slows progression on advanced prostate cancer
PFS extension with immunotherapy + chemotherapy in urothelial cancer
Third-line in mCRPC: CARD trial
Prostate cancer: spare radiotherapy after surgery
Novel mode of action for kidney cancer treatment
Gynaecological Cancers
Ovarian cancer patients benefit from combined maintenance therapy
Combination of PARP inhibition plus chemotherapy in ovarian cancer
PFS benefit with niraparib as first-line maintenance in ovarian cancer
CNS Tumours
Ceritinib in ALK+ NSCLC brain metastases
Solid Tumours/Pan-Tumour Data
Mixed data: AMG 510 in tumours with KRASG12C
DNA profiling of carcinoma of unknown primary should inform treatment
Larotrectinib: safe and effective in TRK fusion-positive tumours
Related Articles
November 26, 2019
PFS benefit with niraparib as first-line maintenance in ovarian cancer
November 26, 2019
IDH1+ cholangiocarcinoma: phase 3 results show improved PFS
November 26, 2019
Prostate cancer: spare radiotherapy after surgery
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