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Study supports link between endosomal-traffic defect and Alzheimer’s

Science Translational Medicine
Reuters Health - 04/12/2020 - New findings confirm that endosomal-trafficking disruption is often involved in Alzheimer's disease. Endosomes are part of the intracellular transport pathway to and from the cell membrane. Endosomal trafficking has recently been validated as a contributor to the pathogenesis of Alzheimer's disease, Dr. Scott A. Small of Columbia University Irving Medical Center, in New York City, explained in an email to Reuters Health. "Still," he added, "it remained possible that this pathway causes the disease only rarely." To investigate, Dr. Small and colleagues screened mice with a neuronal-selective knockout of the core of the retromer complex VPS35. This master conductor of endosomal traffic has been implicated in Alzheimer's disease. The researchers validated "three of the most relevant proteomic findings," namely, the amino terminus of the transmembrane proteins APLP1 and CHL1, and the mid-domain of tau. They then set out "to de...

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