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Psychotherapy following acute pharmacotherapy lowers major depression relapse risk

Journal
JAMA Psychiatry
Reuters Health - 04/12/2020 - Patients with major depressive disorder who receive acute pharmacotherapy followed by psychotherapy may have a lowered risk of relapse or recurrence, a meta-analysis suggests. Researchers examined data from 17 randomized clinical trials that, combined, had a total of 1,208 patients with major depressive disorder who received sequential treatment with pharmacotherapy followed by psychotherapy, and 1,075 in control arms that didn't receive this intervention. The pooled risk ratio for recurrence or relapse was lower with sequential therapy (0.84). "The rationale of the sequential model in depression is to provide psychotherapy after successful response to acute-phase antidepressant medication to improve symptoms that pharmacotherapy was unable to affect, since these treatments have specific, different therapeutic targets," said study co-author Jenny Guidi, a psychology researcher at the University of Bologna in Italy. "Psychotherape...


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