https://doi.org/10.55788/67ecb84b
Dr Maria Petracca (Sapienza University of Rome, Italy) and colleagues set up a single-centre, randomised-controlled study to evaluate the impact of telerehabilitation and on-site rehabilitation, both of 6 weeks duration, in MS patients with a baseline Expanded Disability Status Scale (EDSS) score between 2.0 and 6.5 [1]. Clinical evaluation at baseline and after 6 weeks included Berg Balance Scale (BBS), Symbol Digit Modalities Test (SDMT), Multiple Sclerosis Quality of Life-54 (MSQOL-54), and Fatigue Severity Scale (FSS). Both telerehabilitation and on-site rehabilitation consisted of 18 one-on-one sessions of 45 minutes each. Telerehabilitation sessions were interactive, with whole-body view, via video conference. Each intervention was tailored to the specific needs of the patient. Primary outcomes were longitudinal changes in the aforementioned clinical measures.
The final study population counted 51 participants; 37 were women, mean age was 46.3 years, and median EDSS score was 3.5. In both the telerehabilitation (n=25) and on-site rehabilitation (n=26) group, significant improvements (P<0.01) were observed in all explored outcomes, with no significant between-group differences. For example, the mean MSQOL-54 improved from 54.87 to 60.32 in the on-site rehabilitation group, and from 61.93 to 64.62 in the telerehabilitation group. The mean FSS improved from 5.00 to 4.04 in the on-site rehabilitation group, and from 4.50 to 3.84 in the telerehabilitation group. Among clinical/demographic features, only baseline FSS, BBS, and SDMT scores significantly predicted the respective outcome measure change over time (P<0.01). “Patients with less favourable baseline scores generally experienced less benefit in the tested domains,” Dr Petracca clarified. She concluded that these results validate the telerehabilitation approach in MS patients with moderate disability.
- Petracca M, et al. Effectiveness of telerehabilitation vs on-site rehabilitation on disability, fatigue and quality of life in multiple sclerosis: a randomized clinical trial. O087, MSMilan 2023, 11–13 October, Milan, Italy.
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Table of Contents: MSMilan 2023
Featured articles
Letter from the Editor
Real-world data supports ocrelizumab prior to conception
Progressive MS
Early initiation of highly active treatment associated with a lower risk of SPMS
Ocrelizumab more effective than interferon/glatiramer acetate in older MS patients
Paediatric MS
Prioritising high efficacy therapies in children with MS
Omega-3 polyunsaturated fatty acids associated with lower risk of MS activity
NMOSD & MOGAD
An update on evolving treatment algorithms for NMOSD and MOGAD
Women’s Health
Rate of grey matter brain atrophy accelerates after menopause
Real-world data supports ocrelizumab prior to conception
Miscellaneous
New insights into the contribution of EBV to MS pathogenesis
COVID-19 infection associated with higher MS relapse rate
Telerehabilitation effective in improving MS symptoms in patients with moderate disability
Curing MS
Understanding what an MS cure means and what it takes
Prodromal MS
Progressive brain tissue loss precedes the onset of clinical MS by years
Sickness absence rate increases years before clinical onset of MS
Treatment Trials and MS Strategies
Early intensive treatment enhances long-term clinical outcomes
Oral glycolipid shows promise in the treatment of MS, especially SPMS
Fenebrutinib shows rapid reduction of new Gd+ T1 lesions
Challenges of de-escalation versus discontinuation of highly effective DMTs in older MS patients
Biomarkers & Imaging
χ-separation can assess the effects of tissue destruction in early MS lesions
High sGFAP levels are associated with disease progression, independent of NfL or relapse activity
Broad rim lesions correlate with a rapidly progressive MS phenotype
Smouldering inflammation detectable even in the earliest stages of MS
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