Home > Neurology > Early administration of tranexamic acid potentially harmful in isolated severe TBI

Early administration of tranexamic acid potentially harmful in isolated severe TBI

Journal
JAMA Neurology
Reuters Health - 08/12/2020 - For patients with isolated severe traumatic brain injury (TBI), administering tranexamic acid (TXA) en route to the hospital does not appear to be helpful and might be harmful, according to a Dutch study. "Our study is the first to show that prehospital use of TXA is associated with increased mortality in patients with isolated severe TBI, suggesting that TXA should be used judiciously when no evidence for extracranial hemorrhage is present," Dr. Patrick Schober of Amsterdam University Medical Center in the Netherlands told Reuters Health by email. In a report in JAMA Neurology, he and his colleagues note that TXA has been shown to improve survival in injured patients with severe bleeding mainly by preventing exsanguination. However, exsanguination is typically not a primary concern in TBI, particularly isolated TBI, and the association of TXA administration with TBI outcomes remains unclear. "Previous studies neither provided co...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on