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Nocturnal blood pressure spike tied to increased cardiovascular disease risk

Journal
Circulation
Reuters Health - 02/11/2020 - People who experience elevated nighttime blood pressure are at increased risk of cardiovascular events and heart failure, a Japanese study suggests. Researchers examined data on 6,359 patients with at least one risk factor for cardiovascular events but no symptoms of cardiovascular disease at baseline. Participants had a mean age of 68.6 years at baseline, when they underwent 24-hour ambulatory blood pressure monitoring. After a mean follow-up of 4.5 years, there were 306 cardiovascular events, including 119 strokes, 99 incidents of coronary artery disease, and 88 cases of heart failure. Each 20 mmHg increase in nighttime systolic blood pressure was associated with an elevated risk of atherosclerotic cardiovascular disease (adjusted hazard ratio 1.18) and heart failure (aHR 1.25). Compared with a normal circadian rhythm, a disrupted circadian rhythm with a "riser" pattern of nighttime blood pressure higher than daytime blo...


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