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Vascular invasion, tumor deposits more prognostic than TNM for rectal cancer

Journal
Annals of Surgery
Reuters Health - 30/09/2020 - In patients with rectal cancer, MRI assessment of non-nodal tumor nodules (tumor deposits; mrTDs) and extramural venous invasion (EMVI) are more accurate prognosticators than tumor size and lymph node metastases (mrLNMs), researchers say. "If an MRI scan shows enlarged lymph nodes, the standard course of treatment for rectal cancer currently is radiotherapy," Dr. Gina Brown of Royal Marsden NHS Foundation Trust in London, UK told Reuters Health by email. However, "other factors, such as the spread of the tumor into the veins and their related deposits should be used instead." "Non-nodal tumor nodules have a distinct MRI appearance compared to lymph node metastases and have a serious effect on prognosis that can be reversed by the use of chemoradiotherapy," Dr. Brown said. The study could be "practice changing," she added, "and patients who were previously thought of as being 'high risk' could possibly not be and vice versa." ...


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