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PPIs associated with increased risk of type 2 diabetes

Journal
Gut
Reuters Health - 08/10/2020 - Proton pump inhibitors (PPIs) are associated with increased risk of developing type 2 diabetes, particularly with long-term use, a prospective analysis suggests. Researchers examined data on 204,689 participants without type 2 diabetes at baseline in the Nurses' Health Study (NHS), NHS II, or Health Professionals Follow-up Study (HPFS). After 2.13 million person-years of follow-up, researchers identified 10,105 incident cases of type 2 diabetes. Overall, regular PPI users had a higher risk of developing type 2 diabetes than non-users (hazard ratio 1.24), researchers report in Gut. The risk of type 2 diabetes increased with longer-duration PPI usage, and was lower among those who took PPIs for less than two years (adjusted HR 1.05) than those taking PPIs for more than two years (aHR 1.26), compared with non-users of PPIs. "Physicians should be aware of the potential risk of type 2 diabetes when prescribing PPIs, particularl...


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