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Organ preservation possible in early-stage rectal cancer

Lancet Gastroenterology and Hepatology
Reuters Health - 01/01/2021 - For patients with early-stage rectal cancer, a short course of radiotherapy followed by transanal endoscopic microsurgery (TREC) achieves "high levels" of organ preservation and improved quality of life, a study indicates. "These data support the use of organ preservation for patients considered unsuitable for primary total mesorectal excision due to the short-term risks associated with this surgery, and support further evaluation of short-course radiotherapy to achieve organ preservation in patients considered fit for total mesorectal excision," the study team concludes in The Lancet Gastroenterology and Hepatology. Radical surgery to remove the rectum without preoperative radiotherapy, the current standard of care for early-stage rectal cancer, comes with substantial morbidity and impact on quality of life. The TREC study was a randomized, open-label feasibility study testing a less radical approach. It recruited 55 adults with...

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