Invasive features, positive margins tied to worse outcome of precancerous pancreas lesions

Reuters Health - 16/10/2020 - Invasive pathology and positive surgical margins are associated with worse outcomes after resection of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, researchers in South Korea report. "Outcomes of survival and recurrence differed according to initial pathology and margin status after resection in patients with IPMN," Dr. Hyeong Seok Kim of Seoul National University College of Medicine told Reuters Health by email. "However, even in patients with low-grade dysplasia (LGD) or high-grade dysplasia (HGD), regular follow-up is required after resection of the lesions for the possibility of recurrence after five years and development of pancreatic ductal adenocarcinoma (PDAC) in the pancreas," he said. IPMNs are precancerous lesions of the pancreas, and several studies have sought to identify risk factors to support decisions regarding which patients should undergo surgical resection. Little is known, however, about ...

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Posted on 16 October, 202022 October, 2020