https://doi.org/10.55788/4f3f4ae0
The human body houses around 40 trillion bacteria, viruses, and fungi, creating a microbiome that corresponds roughly to the number of human cells at a 1:1 ratio. Dr Carolina Dantas Machado (UC San Diego, CA, USA) presented the latest findings about how the gut microbiome constantly changes during the day and with seasons [1].
Utilising data from the global American Gut Project, she and her team analysed 18,219 adult stool samples. They reported diurnal signals at various taxonomic levels, with distinct 24-hour cycles in about 60% of the phyla. These findings suggest that human diurnal rhythms might not be apparent in studies with small sample sizes and few controlled confounding variables, though they may still influence study results.
One notable example was the Actinobacteriota phylum, which was identified at lower levels in stool samples collected in the morning compared with those taken during the day. The researchers hypothesised that this could be linked to light exposure.
Seasonal changes were more pronounced with the Proteobacteria phylum, which showed lower levels in winter and a rise during the spring, peaking in summer. Moreover, seasonal fluctuations could be influenced by location, climate, pollen, humidity, and other environmental factors.
These findings offer a potential explanation for the increased susceptibility of humans to common colds and flu during specific seasons, as the microbiome is known to influence the immune response. “The fluctuating microbiome also plays a role in the way drugs are metabolised, which could alter the results of clinical studies if not considered,” emphasised Dr Dantas Machado.
- Dantas Machado AC, et al. The human gut microbiome displays diurnal and seasonal rhythmic patterns. Lecture 395, DDW 2023, 6–9 May, Chicago, IL, USA.
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