Cobitolimod might induce remission in moderate-to-severe left-sided ulcerative colitis

Reuters Health - 26/10/2020 - Topically administered cobitolimod may induce remission in patients with moderate-to-severe left-sided ulcerative colitis (UC), according to results from the phase-2b CONDUCT trial. "Only two local applications of 250 mg cobitolimod, three weeks apart, led to induction of clinical remission already at week 6 in this moderate-to-severe, treatment-refractory ulcerative colitis patient population," Dr. Raja Atreya of University Hospital Erlangen, in Germany, told Reuters Health by email. But outside experts warn that the findings may not pan out. "In previous years, many encouraging compounds that showed positive results in phase 1 or 2 studies have not delivered in phase 3 development programs," write Dr. Christopher Ma and Dr. Remo Panaccione of the University of Calgary, in Alberta, Canada, in a linked editorial. "This risk for cobitolimod is particularly high given that important secondary endpoints, including differences in end...

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Posted on 26 October, 20206 November, 2020