Home > Gastroenterology > Antibiotics prove noninferior to surgery for appendicitis in large trial

Antibiotics prove noninferior to surgery for appendicitis in large trial

Journal
New England Journal of Medicine
Reuters Health - 05/10/2020 - A 10-day course of antibiotics is as effective against appendicitis as traditional surgery, although less effective in patients with appendicolith, according to a new noninferiority trial. With 1,552 randomized participants treated at 25 U.S. medical centers, the study is the largest appendicitis trial ever conducted. At 30 days, quality-of-life scores were essentially identical whether a volunteer was placed in the antibiotics or appendectomy group, while patients in the antibiotic group missed less time at work and school. When antibiotics were given, 29% of the patients ended up receiving surgery within 90 days anyway. "But many of our patients were quick to point out there's a 7 in 10 chance of avoiding surgery," coauthor Dr. David Flum of the University of Washington School of Medicine, in Seattle, told Reuters Health by phone. "Some are going to say, get it over with, I don't want to have the risk. But a lot of other...


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