Home > Once-weekly insulin is a promising treatment option

Once-weekly insulin is a promising treatment option

Presented By
Dr Julio Rosenstock, University of Texas Southwestern, USA
EASD 2020
Phase 2
The once-weekly basal insulin analogue, icodec, showed comparable efficacy and safety to once-daily insulin glargine U100 in a phase 2 study (NCT03751657). Patients with type 2 diabetes who need basal insulin could potentially have a simpler, once-weekly treatment regimen without compromising blood sugar control and safety. The investigational drug, insulin icodec, is a long-acting basal insulin analogue with a half-life of approximately 1 week. After injection, insulin icodec binds strongly but reversibly to albumin, resulting in a slow and steady release of active icodec that lowers blood sugar throughout the week. As it is a concentrated formulation, icodec’s injection volume is equivalent to that of daily glargine U100. Dr Julio Rosenstock (University of Texas Southwestern, USA) and colleagues...

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