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Reduced cardiovascular outcomes with early rhythm control

Presented By
Prof. Paulus Kirchhof, University Heart & Vascular Center Hamburg, Germany
Conference
ESC 2020
Trial
EAST-AFNET 4
  Early initiation of rhythm control reduced cardiovascular outcomes in patients with early atrial fibrillation (AF) and comorbid cardiovascular conditions compared with contemporary, evidence-based usual care [1]. Although early rhythm control was associated with more adverse events, the overall safety of both strategies was comparable and did not affect the number of nights spent in hospital per year. These findings of the EAST-AFNET 4 trial were published simultaneously in the New England Journal of Medicine [2]. Even with current guideline-based management, approximately 5% of AF patients suffer acute coronary syndrome, heart failure, stroke, or cardiovascular death per year [2]. There is an increased risk of cardiovascular complications during the first year after AF is diagnosed. Researchers have hypothesised that rhythm-control therapy may be more effective when delivered early, but evidence supporting ...


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