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Common genetic variants, modifiable risks implicated in hypertrophic cardiomyopathy

Journal
Nature Genetics
Reuters Health - 02/02/2021 - Patients with hypertrophic cardiomyopathy (HCM) who don't carry a rare genetic mutation seem to be affected by common genetic variants, and diastolic blood pressure (BP) is likely a key modifiable risk factor, a genome-wide association study revealed. "We always assumed that common variants would influence the risk of developing cardiomyopathy somewhat, but the effects we found were far greater than we had imagined. And that's why we think there are immediate clinical implications," Dr. Hugh Watkins of the University of Oxford, UK, told Reuters Health by email. "We now know that patients with HCM who do not have one of the rare inherited mutations, instead have developed it because they carry many of the common variants," he said. "This means that the risk of HCM developing in their children is much lower, especially at young ages, and instead we see that high blood pressure is an important component. So now we can both reassure and imp...


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