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CABG grafting risk thresholds differ between men and women

JAMA Cardiology
Reuters Health - 29/12/2020 - Multiple arterial grafting during coronary artery bypass surgery is associated with better outcomes among low-risk, but not high-risk, patients, and the risk cutoffs differ in men and women, according to a large observational study. The evidence on coronary artery bypass grafting (CABG) in women "is really poor" and "we cannot extrapolate to women what we see in studies performed in a prevalently male population (women generally represent 20-25% of patients in CABG studies, much less in randomized controlled trials). It is the time to design CABG studies (including RCTs) specifically for women," Dr. Mario F. L. Gaudino told Reuters Health by email. To examine aspects of these differences, Dr. Gaudino of Weill Cornell Medicine, in New York City and colleagues used New York State data on more than 63,000 patients who underwent CABG between 2006 and 2014. Although most (76%) were men, women generally had worse baseline characteristics, wit...

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