Researchers started a retrospective study to explore the association between psoriasis and chronic kidney diseases (CKD). They conducted a population-based cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES). Logistic regression analyses revealed the potential association between psoriasis and CKD risk. Furthermore, causality was evaluated through a Mendelian randomisation analysis using large-scale genome-wide association studies of psoriasis and CKD. The primary method used was the Inverse variance-weighted (IVW) analysis.
The results showed that of 16,750 participants, 39 out of 429 patients with psoriasis had CKD (9.1%), while the same percentage (9.1%) was observed in 1481 of 16,321 participants without psoriasis. In the fully adjusted model, there was no observed association between psoriasis and CKD (OR: 0.77, 95%CI: 0.53–1.10). For the MR analysis, 36 single-nucleotide polymorphisms (SNPs) were chosen as instrumental variables. The IVW analysis indicated a genetically predicted psoriasis association with a high risk of CKD (OR: 1.025, 95%CI: 1.001–1.049). Even after eliminating 2 SNPs linked to heterogeneity, the association persisted (OR: 1.028, 95%CI: 1.006–1.050).
Investigators concluded that genetically predicted psoriasis was associated with a higher risk of CKD, suggesting a potential causal relationship.
Reference: Yin S, et al. Nephrology 2023;28(11):611-619.
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