Apixaban superior to VKAs for major bleeding, stroke/STE and all-cause mortality

A French observational study comparing different types of non-vitamin K oral anticoagulation (NOAC) showed that 42% to 65% of patients were treated with standard doses of these agents. Analyses of standard doses confirmed the superiority of apixaban when compared to vitamin K antagonists (VKAs) for major bleeding, stroke, and all-cause mortality. Real-world data which compares all currently available NOACs on a nationwide scale are not available. As NOACs are often underdosed in everyday practice, comparing the different agents can be rather complicated. NAXOS, a French real-world study, compared safety (major bleeding), effectiveness (stroke, systemic thromboembolic events [STE]) and all-cause mortality for the NOACs apixaban, dabigatran, rivaroxaban, and VKAs, in adult patients with non-valvular atrial fibrillation (NVAF) who initiated a given NOAC between 2014 and 2016. Analyses were performed with adjustment on propensity scores. To avoid bias potentia...

Please login to read the full text of the article.

If you have no account yet, please register now.

Posted on 10 October, 2019