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Pregnancy after breast cancer

Conference
BCC 2019
Trial
POSITIVE, NCT02308085

Many young breast cancer survivors retain a project of childbearing, but both patients and their physicians have concerns that a pregnancy, with its associated hormone-amplified milieu, will increase the risk for breast cancer recurrence, especially if the disease is hormone-sensitive, i.e., ER–positive. Recently published data showed reassuring data on the long-term safety of pregnancy in breast cancer survivors, including those with ER-positive disease [1]. Whether a break in adjuvant endocrine therapy will compromise breast cancer outcomes is the subject of a large international cooperative group study (POSITIVE; NCT02308085). At the St. Gallen Conference 2019, the panellists were asked to give their opinion on the minimal duration of endocrine therapy before interrupting to allow pregnancy. A majority of 80% took the view that this is allowed after 18 months. A majority of 60% of the panellists endorsed restaging prior to attempted conception. According to the panellists, there is no reason to discourage pregnancy after breast cancer in all non-high-risk situations, irrespective of ER-status.

  1. Lambertini M, et al. J Natl Cancer Inst 2018; 110: 426-429


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