New cable-transmission capsule endoscopy shows high accuracy in detecting upper GI lesions

Cable-transmission magnetically controlled capsule endoscopy (CT-MCCE) demonstrated high sensitivity and specificity in detecting upper gastrointestinal (GI) lesions compared with conventional gastroscopy, while avoiding adverse events.

Dr Yuan Tian (Peking University First Hospital, China) presented the results of a prospective, multicentre, self-controlled clinical trial conducted between October 2022 and May 2023 [1]. The study enrolled 180 participants aged between 18 and 75 years with upper GI diseases. It evaluated the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CT-MCCE in detecting focal lesions within the oesophagus, stomach, and duodenal bulb, using conventional gastroscopy as the reference.

In the per-protocol analysis, CT-MCCE demonstrated high sensitivity (97.2%) and specificity (100.0%) for detecting oesophageal lesions, with a PPV of 100%, an NPV of 98.2%, and overall accuracy of 98.9%. For gastric focal lesions, CT-MCCE showed a sensitivity of 96.8%, specificity of 98.8%, PPV of 98.9%, NPV of 96.6%, and accuracy of 97.8%. The full analysis set confirmed the high sensitivity and specificity for detecting upper GI lesions.

CT-MCCE successfully identified 1 advanced gastric carcinoma, 1 oesophageal cancer, and 2 early-stage oesophageal tumours, without missing any significant lesions like tumours or large ulcers. CT-MCCE also caused significantly less discomfort than oesophagogastroduodenoscopy (P<0.001). No adverse events were reported among the 180 participants throughout the study period.

“CT-MCCE matches the effectiveness of oesophagogastroduodenoscopy in upper GI examinations and lesion detection, with enhanced patient comfort and no adverse effects Therefore, this innovative CT-MCCE system may be an effective tool for upper GI evaluations,” Dr Tian concluded.

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   1. Tian Y, et al. Prospective, multicenter, self-controlled clinical trial on the effectiveness and safety of a novel cable-transmission magnetically controlled capsule endoscope system for the examination of upper gastrointestinal diseases. 1057f, DDW 2024, 18–21 May, Washington DC, USA.

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Posted on 11 July 202411 July 2024