Overweight/obese BMI linked to worse survival in young people with leukemia

Physician’s Weekly – 06/09/2023 – For adolescents and young adults with acute lymphoblastic leukemia (ALL), overweight/obese body mass index (BMI) is associated with worse outcomes, according to a study recently published in Blood Advances. Dr Shimony (Tel Aviv University, Israel) and colleagues examined the impact of BMI on outcomes of 388 adolescents and young adults aged 15 to 50 years with ALL treated on Dana-Farber Consortium regimens from 2008 to 2021. Overall, 207 participants and 181 participants had normal BMI and overweight/obese BMI, respectively. The researchers found that patients with overweight/obese BMI had higher non-relapse mortality (4-year: 11.7 vs 2.8 percent), worse event-free survival (4-year: 77.63 vs 63.77 percent), and worse overall survival (OS; 4-year: 64 vs 83 percent). Separate analyses were conducted among those aged 15 to 29 years, who more often had normal BMI (79 vs 20 percent). Younger and older (30 to 50 years) adolescents and young adults with normal BMI had excellent OS (4-year: 83 and 85 percent, respectively). However, among adolescents and young adults with overweight/obese BMI, OS was worse in older adolescents and young adults (four-year: 55 versus 73 percent).

Reference: Shai Shimony, et al. Blood Adv 2023;7(18). https://doi.org/10.1182/bloodadvances.2023009976

 

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Posted on 19 September 202319 September 2023