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Urinary fetuin-A peptides a potential biomarker for renal dysfunction in diabetics

Journal
Clinical Kidney Journal
Reuters Health - 05/11/2020 - In patients with type 2 diabetes, urinary fetuin-A peptides was associated with impaired kidney function before albuminuria appeared, in a proteome data analysis. "Fetuin-A peptides had a significant added value to albuminuria, the currently used method to detect impaired kidney function," Dr. Petra Zuerbig of Mosaiques Diagnostics GmbH in Hannover, Germany, told Reuters Health by email. "The findings confirmed the use of CKD273, a proteomic-based classifier, which also includes fetuin-A peptides. This test is well established and was already used in a clinical trial for the early detection of diabetic kidney disease." (https://bit.ly/34Z7PyA) As reported in the Clinical Kidney Journal, Dr. Zuerbig and colleagues analyzed urinary peptides from 1,491 diabetic patients with (647) and without (844) kidney disease. Those with diabetic kidney disease (DKD) had a mean age of 64; mean eGFR of 49.36 mL/min/1.73(2); and urinary albumin excretion...


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