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Psoriasis: Disrupted gut-skin axis

Presented By
Dr Mariusz Sikora, Medical University of Warsaw, Poland
WPPAC 2021
An evolving field is the impact of microbiota and the intestinal barrier on the pathophysiology of chronic inflammatory diseases, including psoriasis and psoriatic arthritis. Psoriasis contributes to the disruption of the intestinal barrier integrity and to the translocation of bacterial metabolites. This can activate the inflammatory response, leading to the exacerbation of skin lesions. Increasing evidence from experimental and clinical studies suggests an important role for the interaction between an altered intestinal microbiome (dysbiosis), intestinal barrier damage, and the immune system in the pathogenesis of psoriasis. These findings triggered research towards the gut-skin axis. Dr Mariusz Sikora (Medical University of Warsaw, Poland) and colleagues studied the influence of the disease activity of psoriasis on the intestinal barrier permeability and the blood concentration of bacterial metabolites and its clinical implications, such as the p...

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