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Potential role of inflammation in cardiovascular comorbidity

Presented By
Dr Alexander Egeberg, Herlev and Gentofte Hospital, Denmark
Conference
WPPAC 2021
Trial
Phase 3, CANTOS, CIRT
Systemic inflammation appears to play a role in psoriasis comorbidities. However, the magnitude of this effect remains unclear. Bias and residual confounding are major limiting factors in many existing studies in patients with psoriasis. Dr Alexander Egeberg (Herlev and Gentofte Hospital, Denmark) discussed the association between psoriasis and cardiovascular comorbidities. Systemic inflammation in psoriasis shows similarities with the inflammation observed in cardiovascular disease, specifically related to atherosclerosis; for example, the role of the IL-23/Th17 pathway [1,2]. “An interesting question is whether we can prevent this by treatment of psoriasis,” Prof. Egeberg suggested. Negative studies The CANTOS study (NCT01327846) evaluated whether the treatment of inflammation, independent of psoriatic disease, could lower the ris...


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