Home > Rheumatology > ACR 2020 > Osteoarthritis – Novel Developments > Knee osteoarthritis patients with indicators of inflammation could profit from methotrexate

Knee osteoarthritis patients with indicators of inflammation could profit from methotrexate

Presented By
Prof. Biswadip Ghosh, Institute of Post Graduate Medical Education and Research, India
Conference
ACR 2020
Patients with osteoarthritis and signs of inflammation showed benefit when treated with methotrexate. In a new trial, improvements were observed in both systemic markers of inflammation and also joint function. The concept of local as well as systemic inflammation increasing joint impairment in osteoarthritis (OA) seems increasingly acknowledged [1]. “We see patients with OA almost every day who are usually advised non-pharmacological interventions and analgesics only, until the pain is unbearable and then they are asked to go for knee replacement,” Prof. Biswadip Ghosh (Institute of Post Graduate Medical Education and Research, India) described the current situation [2]. “Most patients suffering from knee OA have episodes of inflammation and each episode not only increases the pain but also further damages the joint,” he further pointed out. The presented trial assessed the efficacy of methotrexate versus glucosamine as a substitute for placebo in ...


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