Home > Rheumatology > EULAR 2022 > Spotlight on Rheumatoid Arthritis > Comorbid depression comes with a profoundly higher mortality risk in RA

Comorbid depression comes with a profoundly higher mortality risk in RA

Presented By
Dr Jens Kristian Pedersen, Odense University Hospital, Denmark
Conference
EULAR 2022
Doi
https://doi.org/10.55788/b4eb10de
According to a large, Danish register analysis, the risk of mortality rises markedly for patients with rheumatoid arthritis (RA) who are also diagnosed with depression. In those younger than 55 years, the risk was increased more than 6 times. A high prevalence of depressive disorders and links between depression and various long-term outcomes in RA have been observed [1]. “Although antidepressants are used for different indications, we have recently described that, in RA, the most frequent indication for filling antidepressants is depression,” Dr Jens Kristian Pedersen (Odense University Hospital, Denmark) stated [2,3]. The presented cohort study investigated the mortality risk in patients with incident RA and depression [3]. Data was collected from various nationwide Danish registries. The presence of depression was defined as the first filling of an antidepressant prescription. The follow-up period for the all-cause mortality risk was from January 2008 t...


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