The proportion of people in the USA who smoke has decreased from 20.9% in 2005 to 13.7% in 2018 [2]. Yet, within the smoking population, the rate of so-called light smokers has risen from 16% to 27% [3]. A good reason to look at the risk of mortality of respiratory disease and lung cancer in these smokers, who probably think that their smoking entails a low risk.
Dr Pallavi Balte (Columbia University, USA) presented results from the NHLBI pooled cohort study [1]. Dr Balte and colleagues harmonised data from 4 cohorts with information on the general population including 18,730 participants with consistent smoking status. Smokers were classified according to their number of cigarettes per day (CPD) into light/social smoker (<10 CPD), smokers (10-20 CPD), and heavy smokers (>20 CPD). To calculate their risks, a Cox proportional hazard regression was fit that adjusted for potential confounders like sex, age, race, education, and weight. The outcome of respiratory mortality was classified using the International Classification of Diseases (ICD)-9 and IC-10 codifications for several diseases, including asthma, emphysema, COPD, chronic bronchitis, and respiratory failure. Likewise, lung cancer mortality was also defined by ICD-9 and ICD-10 codes. Participants were followed up for a median of 17 years. They had a mean age of 63 years, 69% were Caucasian, 56% were female, and 2% were light and 8% were heavy smokers.
The incidence density rate was calculated in cases per 10,000 person-years with 20 for respiratory mortality and 17 for lung cancer mortality. Light smoking lead to a risk of respiratory mortality that was 2.5 times greater than the risk for non-smokers and had a nearly 9 times higher likelihood of lung cancer mortality (HR 8.6). Interestingly, light smoking was also associated with a risk for respiratory mortality and lung cancer mortality that was as high as 49% and 71% of the risk of heavy smokers.
“In conclusion, our findings suggest that low-intensity smoking is disproportionately harmful and in order to reduce the risk of dying from respiratory disease or lung cancer the best action is to quit smoking completely,” was the bottom line according to Dr Balte.
- Balte P, et al. Association of low-intensity smoking with respiratory and lung cancer mortality. Abstract 4389, ERS International Virtual Congress 2020, 7-9 Sept.
- Centres for Disease Control and Prevention. Retrieved from: https://www.cdc.gov/tobacco/data_statistics/fact_sheets/adult_data/cig_smoking/index.htm [Accessed on 30 September 2020].
- Hackshaw A, et al. BMJ. 2018;360:j5855.
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Table of Contents: ERS 2020
Featured articles
COVID-19 and the Lung
COVID-19 infections: Bronchoscopy provides additional diagnostic certainty
COVID-19 vaccines: An ongoing race
COVID-19: What is the risk of reinfection?
COVID-19 App: The Dutch experience
Secondary pulmonary fibrosis: a possible long-term effect of severe COVID-19
COVID-19 survivors benefit from structured follow-up
Early pulmonary rehabilitation post-COVID-19 aids recovery
Asthma – What's New
Mild asthma: A fundamental change in management
Dupilumab shows long-term efficacy in asthma patients
Severe asthma: Oral corticosteroids maintenance therapy associated with toxicity
First-in-class tyrosine kinase inhibitor shows promise in severe asthma
Predicting individual effectiveness of biologics in severe asthma
IL-5 antagonist showed efficacy in chronic rhinosinusitis with nasal polyps
Treatment according to genotype: The future of asthma therapy?
COPD – The Beat Goes On
The role of chronic symptoms as early biomarkers of COPD development
Urgent call for studies in COPD patients aged 40-60 years
Nasal high-flow therapy: a novel treatment option for hypercapnic COPD patients
Exacerbation history is a reliable predictor of future exacerbations
Singing training effective as physical rehabilitation in COPD
Current prediction tools underestimate exacerbation risk of severe COPD patients
Exercise and Sleep: From Impaired Function to New Therapeutic Strategies
CPAP withdrawal has negative consequences for sleep apnoea patients
Physical activity improves AHI in sleep apnoea patients
The Tobacco Epidemic: From Vaping to Cannabis
Poly-use of nicotine products and cannabis: a deadly combination
E-cigarettes: A source of chronic lung inflammation
Social smoking: Do not underestimate the risks
Chronic Cough – State of the Art
LEAD study shows multiple phenotypes in many chronic cough patients
First-in-class P2X3 receptor antagonist shows promise for chronic cough treatment
Lung Cancer Detection
Lung cancer screening: Most patients not eligible 1-2 years prior to diagnosis
Distinct changes in lung microbiome precede clinical diagnosis of lung cancer
Best of Posters
Smartphone-based cough detection helpful in predicting asthma deterioration
Reduced lung function associated with cognitive decline in the elderly
Longer hospital stay and fewer transplants for frail ILD patients
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