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Inhaled corticosteroids useful in preterms with decreased lung function

Presented By
Prof. Shannon Simpson, Curtin University, Australia
Conference
ERS 2022
The use of inhaled corticosteroids improved the lung function of prematurely born children in a randomised-controlled trial. The results suggest that bronchodilator responsiveness (BDR) may be used to screen eligible patients for this approach. Preterm associated lung disease is a common complication and evidence indicates that the lung function of these preterm patients worsens over time [1,2]. A randomised, clinical trial demonstrated that inhaled corticosteroids may be administered to improve lung function in preterm-born children [3]. The current Preterm Paediatric Inhaled Corticosteroids Intervention (PICSI) study, conducted by Prof. Shannon Simpson (Curtin University, Australia) and colleagues, randomised 170 survivors of very preterm birth (≤32 weeks gestation) to a 12-week course of the inhaled corticosteroid fluticasone propionate or to placebo. A modest but significant difference in % FEV1-change was observed between the fluticasone arm (5...


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