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Head-to-head: lung volume reduction surgery vs endobronchial valves

Presented By
Ms Sara Buttery, Royal Brompton and Harefield NHS Foundation Trust, UK
Conference
ERS 2022
Trial
CELEB
Lung volume reduction surgery (LVRS) was not significantly superior to bronchoscopic lung volume reduction (BLVR) with valve placement in patients with emphysema who were eligible for both treatment options. These important findings to guide treatment decisions are currently being evaluated in a larger trial. Although LVRS and endobronchial valves (EBVs) have both demonstrated to improve lung function, exercises capacity, and quality-of-life for patients with emphysema, no existing clinical trials have directly compared LVRS with the use of EBVs [1,2]. The randomised, single-blind CELEB trial (ISRCTN19684749) assessed whether LVRS was superior to BLVR in patients with emphysema who were suitable for both procedures (n=88) [3]. The primary endpoint was the i-BODE index score at 12 months, a measure that includes FEV1% predicted, exercise capacity, dyspnoea, and BMI. M...


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