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Antibiotics are harmful in severe RSV bronchiolitis

Presented By
Prof. Avraham Beigelman , Schneider Children's Medical Center of Israel, Israel
ERS 2022
The antibiotic agent azithromycin should be avoided in patients with early-life, severe respiratory syncytial virus (RSV) bronchiolitis, for it has been associated with an increased risk for subsequent recurrent wheezing. Other antibiotics are likely to have the same harmful effect. “Leave the kids alone,” pleaded the key author of the study. Recurrent wheezing and asthma often occur after severe RSV bronchiolitis [1]. Aiming to solve this clinical problem, Prof. Avraham Beigelman (Schneider Children's Medical Center of Israel, Israel) and co-investigators developed a randomised trial to analyse whether azithromycin outperformed placebo with respect to recurrent wheezing in hospitalised patients with RSV bronchiolitis (n=200; 1–18 months of age). The primary results did not demonstrate a difference between placebo and azithromycin on recurrent wheezing after an RSV infection [2]. During his talk at ERS 2022, Prof. Beigelman presented the results of a post-...

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