Previous literature shows that 1 in 3 infants develop recurrent wheeze or asthma after bronchiolitis [1]. Respiratory viruses are the primary cause of bronchiolitis in infants. While there appears to be a causal relationship between RSV or RV infection and asthma development, research has only compared outcomes of RSV and RV bronchiolitis. This is the first systematic review to directly compare the associations of RSV and RV bronchiolitis with preschool wheeze and asthma development.
To this end, 4 databases were searched for articles using a MeSH term-based algorithm. After screening, 48 studies were included in the meta-analysis which was limited to cohort studies and randomised controlled trials. Outcomes of interest were recurrent wheeze and diagnosis of asthma.
Results showed that children with RV bronchiolitis were more likely to develop asthma than children with RSV (OR 2.49; 95% CI 1.41–4.40). In addition, the RV bronchiolitis group was more likely to develop recurrent wheeze than the (OR 4.55; 95% CI 2.01–10.29).
According to Dr Heidi Makrinioti (Imperial College London, UK), in this first meta-analysis comparing RSV- and RV-induced bronchiolitis as a risk factor for recurrent wheeze and asthma, recurrent wheeze and asthma were more likely to occur after RV bronchiolitis than after RSV bronchiolitis. Thus, future studies should focus on infants with RV bronchiolitis as a risk group.
- Makrinioti, H. et al. The role of respiratory syncytial virus and rhinovirus in early recurrent wheeze and asthma inception – a systematic review. Abstract ERS 2021, 5–8 September.
Copyright ©2021 Medicom Medical Publishers
Posted on
Table of Contents: ERS 2021
Featured articles
Letter from the Editor
COVID-19 Research: Looking Back and Moving Forward
Higher inflammation markers in COVID-19 patients with a first negative PCR test
Persistent fatigue following COVID-19
Risk of COVID-19-related morbidity and mortality in young and middle-aged adults
Respiratory Viral Infections: Insights from Recent Studies
Rhinovirus bronchiolitis increased risk of recurrent wheezing and asthma
COPD: Evidence Update
Livestock farming affected the airway microbiome of COPD patients
Reduction of COPD severe acute exacerbations by candidate vaccine
Paediatrics and Vaccinology
Better lung function in children with a healthy diet
Need for validated severity score in the assessment of bronchiolitis
Increased impact of air pollution on lung function in preterm infants
Pearls in Asthma Research
Biomarkers do not discriminate severe from severe uncontrolled asthma
Increased blood neutrophiles in patients with obesity and asthma
Blood inflammatory phenotypes associated with clinical symptoms of asthma
site created by:
© 2024 Medicom Medical Publishers. All rights reserved. Terms and Conditions | Privacy Policy