Tumor characteristics in ‘exceptional responders’ may point to therapies for others

Reuters Health - 25/11/2020 - A molecular analysis of tumors from patients who had exceptionally good responses to cancer treatments has helped researchers identify potential targets for patients who don't respond as well to standard therapies, researchers say. In a study of tumors from more than 100 exceptional responders, the study team identified genetic and microenvironment changes, many of which revealed plausible mechanisms for the response that could be exploited in the future, according to the report published in Cancer Cell. "The major take home message from this study is that one can understand exceptional responses by molecular analysis of tumors," said Dr. Louis Staudt, director of the National Cancer Institute's Center for Cancer Genomics in Bethesda, Maryland. "That didn't have to be the case," said Dr. Staudt, who co-led the research. "You could imagine that there was something about the patients' constitutions, whether they were healthier or t...

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Posted on 25 November, 20204 December, 2020