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Partial breast irradiation could be as effective as whole breast irradiation

Conference
SABCS 2019
Trial
Phase 3, APBI IMRT

Results of a 10-year follow-up study of breast cancer patients who had been treated with accelerated partial breast irradiation after surgery demonstrated that the rates of recurrence were similar to those of patients who were treated with whole breast irradiation. Based on these findings, accelerated partial breast irradiation should be considered a reasonable alternative for whole breast irradiation in early breast cancer patients.

A total of 520 women aged >40 years with stage 1 or stage 2 breast cancer (with a maximum pathological tumour size of 25 mm and final surgical margins ≥5 mm) were included in the randomised phase 3 APBI IMRT trial [1]. Between 2005 and 2013, the patients were randomly assigned in a 1:1 ratio to receive either accelerated partial breast irradiation or whole breast irradiation. The patients in the accelerated partial breast irradiation arm (n=260) received a total of 30 Gray (Gy) of radiation to the tumour bed in 5 daily frac...



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