What would a “grand cru” from Burgundy have in common with a major oncology congress? Both have remarkable vintage years – which will be remembered for long – and others are less extraordinary, even though of sound quality and careful assembly – still worth your palate, or eyes and ears. We were spoiled by a remarkable succession of groundbreaking ESMO congresses these last years. I’m afraid this year was not a “millésime”– even though, as always, of high quality. I am sure that you will still find enough new research results and practice-relevant information to keep you satisfied.
I hope you will also be satisfied with our picks of relevant presentations. To be able to include a maximum of information, we decided to wrap up some presentations in shorter form (“More highlights in..”). We hope you appreciate the effort.
Please enjoy this year’s ESMO Medicom Conference Report.
Yours, sincerely,
Dr Stefan Rauh
Biography
Dr Stefan Rauh is currently working as oncologist/haematologist in the oncology department of Centre Hospitalier Emile Mayrisch, Esch, Luxembourg. He is mainly involved in clinical work but also in research and teaching activities and is interested in public policy and international cooperation projects in oncology. He is a member of the ESMO Practicing Oncologist’s Working Group since 2011 (chair 2014–2018), member of the ESMO Public Policy Committee, and has been an ESMO Executive Board member in 2015–2016. He is interested in survivorship of cancer patients
and has published a clinician’s handbook on this topic: Survivorship Care for Cancer Patients.
Conflict of Interest Statement: Nothing to declare.
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Table of Contents: ESMO 2024
Featured articles
Meet the Trialist: Prof. Fred Saad shares insights from the ARANOTE trial
Gastrointestinal Cancer
Neoadjuvant chemoradiation does not improve surgical outcomes or survival in pancreatic cancer
Adding lenvatinib plus pembrolizumab to TACE improves PFS in intermediate-stage HCC
Benefit of adjuvant atezolizumab/bevacizumab in HCC not maintained over time
Pre-operative chemoradiation does not improve survival in resectable gastric cancer
Final results of the IKF-AIO-Moonlight trial
Gastrointestinal: Colorectal Cancer
Retifanlimab boosts survival in patients with anal cancer
NICHE-2 and NICHE-3 show high efficacy of short neoadjuvant immunotherapy in dMMR colon cancer
Organ-preserving regimens in rectal cancer
No benefit of high-dose vitamin D3 supplementation in mCRC
Breast Cancer
Trastuzumab deruxtecan also effective in patients with brain metastases
High pCR rates with dual neoadjuvant immunotherapy in TIL-high TNBC
Local HER2 IHC0 is often HER2-low or -ultralow
First-line capivasertib improves PFS but not OS in metastatic TNBC
Breastfeeding does not increase the risk of breast cancer recurrence
Lung Cancer
Adjuvant durvalumab does not improve survival in completely resected NSCLC
NVL-655: a promising new option in pre-treated, drug-resistant ALK-mutated NSCLC
Relatlimab addition benefits only a subgroup of metastatic NSCLC
Melanoma
Neoadjuvant nivolumab/ipilimumab improves DMFS in stage III resectable melanoma
New neoadjuvant combinations in stage III melanoma
Genitourinary Cancer
Rethinking immune rechallenge: Tivozanib monotherapy emerges as a promising post-ICI option in metastatic RCC
Perioperative durvalumab combined with neoadjuvant chemotherapy improves survival in bladder cancer
Watchful waiting is non-inferior to BCG in patients with T0 after second transurethral resection
Faecal transplants show promise in enhancing metastatic RCC treatment
Genitourinary: Prostate Cancer
Combination of radium-223 and enzalutamide benefits patients with mCRPC with bone metastases
177Lu-PSMA effective both in mCRPC and mHSPC
Decipher score is predictive for docetaxel-benefit in mestastatic prostate cancer
Final OS for CONTACT-02 trial in mCRPC
Gynaecological Cancer
Increased OS with pembrolizumab in newly diagnosed, high-risk, locally advanced cervical cancer
Doublet maintenance therapy does not outperform monotherapy in ovarian cancer
Benefit of pembrolizumab in dMMR, newly diagnosed, high-risk endometrial cancer
No OS benefit of niraparib maintenance in high-risk ovarian cancer
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