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Pathway from air pollution to lung cancer in non-smokers identified

Presented By
Dr Charles Swanton, University College London, UK
Conference
ESMO 2022
Increasing exposure to 2.5 µm particulate matter (PM2.5) increases the risk of non-small cell lung cancer (NSCLC) in non-smoking individuals with EGFR mutations. This effect is driven by an influx of macrophages and an increase in the inflammatory mediator IL-1β, which promotes carcinogenesis in airway cells, a study from the University College London showed. Although smoking is the most important cause of lung cancer, non-smokers can also develop this disease. Evidence exists to link air pollution exposure with lung cancer incidence and mortality [1,2]. However, the molecular mechanism underlying the link between air pollution and lung cancer in non-smokers has not been elucidated. Dr Charles Swanton (University College London, UK) presented results from a study that suggests air pollution to accelerate carcinogenesis of EGFR-mutated lung epithelium cells in non-smokers [3]. Lung cancer in non-smokers (LCINS) is a disease with a ...


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