In this episode (21:43 min), Medicom’s correspondent covers 6 presentations from the European Lung Cancer Congress (ELCC 2022) which was held virtually this year with over 2,200 participants from over 95 countries, between the 30th March- 2nd April 2022.
- Furmonertinib outperforms gefitinib as first-line therapy in patients with EGFR-mutated NSCLC
In the phase 3 FURLONG study, third-generation tyrosine kinase inhibitor (TKI) furmonertinib significantly prolonged progression-free survival (PFS) in patients with treatment-naïve, EGFR-mutated, stage IIIB-IV non-small cell lung cancer (NSCLC), compared with gefitinib. - Sintilimab plus chemotherapy improves OS in treatment-naïve stage III/IV non-squamous NSCLC
The final results of the phase 3 ORIENT-11 trial show improved overall survival (OS) in patients with treatment-naïve stage III/IV non-squamous non-small cell lung cancer (NSCLC) treated with sintilimab plus chemotherapy versus placebo plus chemotherapy. - In concurrent chemoradiotherapy for stage III, unresectable NSCLC, proton-therapy bests photon therapy
In a Dutch study, performance status after concurrent chemoradiotherapy was better if patients were treated with protons than with photons, potentially increasing eligibility for adjuvant durvalumab. - Characteristics of long-term survivors in the CASPIAN trial
Long-term survivors in the CASPIAN trial share common favourable – and potentially predictive – clinical and molecular characteristics. This was demonstrated in a subanalysis of the phase 3 trial investigating durvalumab in extensive-stage small cell lung cancer (ES-SCLC). - Immunotherapy delays deterioration in health-related quality of life in metastatic NSCLC
The phase 3 POSEIDON study previously showed that addition of immunotherapy (durvalumab or durvalumab/tremelimumab) to chemotherapy improved survival of patients with metastatic non-small cell lung cancer. Patient-reported outcomes now indicate that deterioration of health-related quality of life is delayed. - No long-term benefit of adding ipilimumab to pembrolizumab in metastatic NSCLC
Although the addition of ipilimumab to first-line nivolumab improved survival of patients with metastatic NSCLC, long-term results from KEYNOTE-598 show that adding ipilimumab to first-line pembrolizumab does not improve survival of patients with metastatic NSCLC and PD-L1 ≥50%.
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Table of Contents: ELCC 2022
Featured articles
Early-Stage Non-Small Cell Lung Cancer
Real-world treatment and survival in early-stage NSCLC
Consistent efficacy of osimertinib in Chinese and global population
Promising efficacy of neoadjuvant osimertinib in EGFR-mutated NSCLC
Peri-operative survival in bilobectomy is comparable with that of left pneumonectomy
Advanced Non-Small Cell Lung Cancer
Pro-inflammatory tumour profile predicts complete pathological response to neoadjuvant chemoimmunotherapy
Furmonertinib outperforms gefitinib as first-line therapy in patients with EGFR-mutated NSCLC
Second-line oritinib demonstrated potential clinical benefit in advanced EGFR-mutated NSCLC
Updated results confirm efficacy and safety of entrectinib in patients with NTRK fusion-positive NSCLC
ROS1 rearrangement-targeting unecritinib is a potential new first-line strategy
Savolitinib is effective in patients with MET-mutated NSCLC
Sintilimab plus chemotherapy improves OS in treatment-naïve, stage III–IV non-squamous NSCLC
Updated results of CameL-sq trial confirm benefit of camrelizumab
No long-term benefit of adding ipilimumab to pembrolizumab in metastatic NSCLC
In concurrent CRT for stage III, unresectable NSCLC, performance status is better with proton therapy than photon therapy
No improved prognosis for concurrent versus sequential immune checkpoint inhibition and CRT in unresectable NSCLC
Durvalumab after sequential CRT safe in stage III, unresectable NSCLC
No impact of grade ≥2 pneumonitis on patient-reported outcomes in PACIFIC
Immunotherapy delays deterioration in health-related quality of life in metastatic NSCLC
Small Cell Lung Cancer
Total metabolic tumour volume: a new potential prognostic factor in SCLC
Radiation dose on oesophagus predicts OS in SCLC patients treated with chemoradiotherapy
Characteristics of long-term survivors in the CASPIAN trial
Outcomes of real-world CANTABRICO trial match results from CASPIAN
Lung Cancer Epidemiology
Lung cancer diagnosis with liquid biopsy of peripheral blood cells
Rare EGFR mutations as oncogenic drivers
Decline in lung cancer mortality is almost exclusive to men
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