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DNA-methylation test shows promise in bladder-cancer detection, monitoring

Journal
Journal of Clinical Investigation
Reuters Health - 07/09/2020 - An assay using methylation markers may offer an alternative to more costly, invasive methods for bladder cancer (BCa) detection and surveillance, according to a new study. "Urine tumor DNA methylation assessment for early diagnosis, minimal, residual tumor detection and surveillance in bladder cancer is a rapid, high-throughput, non-invasive and promising approach, which may reduce the burden of cystoscopy and blind second surgery," Dr. Tianxin Lin of Sun Yat-sen University in Guangzhou, China, and colleagues write in the Journal of Clinical Investigation. About three-quarters of patients with BCa have non-muscle-invasive (NMIBC) disease, and most of these will recur, the authors note. Cystoscopy and cytology are the gold standard for monitoring patients, they add, although cytology has low sensitivity, particularly for low-grade disease. While UroVysion fluorescence in situ hybridization (FISH) is more sensitive, it is also less...


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