
It’s my pleasure and privilege to introduce you to our report of the 2024 ASCO Annual Conference.
Quite a dense program, including issues which deserved to be evidence-based, even though you already did them the right way (i.e. not performing systematic lymphadenectomy in advanced ovarian cancer; keeping radiotherapists away from your patients with resectable oesophageal or borderline resectable pancreas cancer) or which you’ll finally never do, though sometimes tempted to (i.e. debulking of metastatic colorectal cancer). If you like zombie movies: Metformin has again been buried as an active anti-cancer drug, though I’m sure it will wobble out of the grave anew.
What about the drugs? More consolidation on the right use at the right time, vaccines, conjugates… A targeting agent in ovarian cancer shows promise; this is long-awaited progress.
ctDNA seems to broaden its role as an important predictor of treatment efficacy – but clearly also needs careful validation (KEYNOTE-361).
Good news for visualists: providing “palliative care” seems to work on screen as well as face-to-face (of course, depending on your definition of palliative care).
Take your time, stroll through our articles – and maybe also through the ASCO website. However, there’s no study yet proving that strolling through ASCO Annual virtually is equivalent to being on-site.
Yours, sincerely,
Dr Stefan Rauh, FESMO
Biography
Dr Stefan Rauh is currently working as haemato-oncologist in the oncology department of Centre Hospitalier Emile Mayrisch, Esch, Luxembourg. He is mainly involved in clinical work but also in research and teaching activities and is interested in public policy and international cooperation projects in oncology. He is member of the ESMO Practicing Oncologist’s Working Group since 2011 (chair 2014-2018), member of the ESMO Public Policy Committee, and has been an ESMO Executive Board member in 2015-2016. He is coauthor of the 2017 ESMO European Cancer Patient Coalition (ECPC) Patient Survivorship Guide and an invited expert for the ECPC.
Conflict of Interest Statement: Nothing to declare.
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Table of Contents: ASCO 2024
Featured articles
Meet the Trialist: Prof. Giuseppe Curigliano on DESTINY-Breast06
Gastrointestinal: Colorectal Cancer
No survival benefit of tumour debulking for patients with multi-organ metastatic CRC
Thermal ablation of small-size colorectal liver metastases is non-inferior to resection
Benefit of first-line nivolumab/ipilimumab in MSI-H/dMMR metastatic CRC
CodeBreaK 300: Promising survival trends in KRAS G12C-mutated mCRC
Gastrointestinal: Upper GI Cancer
FLOT outperforms CROSS in resectable oesophageal cancer
Nivolumab/ipilimumab combination outperforms TKIs in unresectable HCC
No advantage of neoadjuvant radiochemotherapy over neoadjuvant chemotherapy in borderline resectable pancreatic cancer
Breast Cancer
Benefit of abemaciclib plus fulvestrant after progression on a CDK4/6 inhibitor
ctDNA is prognostic of worse outcomes for CDK4/6 therapy
Adjuvant avelumab significantly improves survival in early TNBC
High pCR rate after neoadjuvant Dato-DXd plus durvalumab therapy
Lung Cancer
Osimertinib significantly improves PFS in patients with unresectable stage III EGFR-mutated NSCLC
First-line lorlatinib provides unprecedented improvement for patients with advanced ALK-positive NSCLC
Comparable benefit of video- and in-person-delivered palliative care
Consolidation with durvalumab improves survival in LS-SCLC
Subcutaneous amivantamab non-inferior and more convenient than intravenous amivantamab
Melanoma
Highly significant event-free survival benefit with neoadjuvant nivolumab/ipilimumab in stage III melanoma
Neoadjuvant intralesional daromun improves relapse-free survival in stage III melanoma
Intratumoural tilsotolimod shows no benefit for advanced refractory melanoma
Genitourinary Cancer
Immune-enhancing nutrition does not affect complication rate of radical cystectomy
ctDNA changes as biomarker for pembrolizumab response in advanced urothelial carcinoma
Highest efficacy of nivolumab/chemotherapy in lymph-node-only metastatic urothelial carcinoma
Genitourinary: Prostate Cancer
Metformin does not prevent progression of low-risk prostate cancer
Baseline ctDNA has both prognostic and predictive value in mCRPC
Oxybutynin significantly decreases frequency and severity of hot flashes in men on ADT
Gynaecological Cancer
Batiraxcept shows promise in high AXL-expressing, platinum-resistant ovarian cancer
No lymphadenectomy for advanced ovarian cancer without suspicious nodes
SIENDO: Efficacy benefit of selinexor in TP53 wildtype endometrial cancer
Novel regimen for HR-positive endometrial cancer on the way?
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