Home > Oncology > ASCO 2022 > Gynaecological Cancers > Trabectedin not superior to chemotherapy in recurrent epithelial ovarian cancer 

Trabectedin not superior to chemotherapy in recurrent epithelial ovarian cancer 

Presented By
Dr Domenica Lorusso, San Raffaele Scientific Institute, Italy
Conference
ASCO 2022
Trial
Phase 3, MIT023
Doi
https://doi.org/10.55788/82538bd1
Trabectedin failed to show a clinical benefit over standard-of-care chemotherapy in patients with BRCA-mutated or BRCAness phenotype, recurrent epithelial ovarian cancer. Nonetheless, translational studies are ongoing to identify potential predictive biomarkers of response to trabectedin.  Trabectedin in combination with pegylated liposomal doxorubicin (PLD) is an approved treatment for patients with platinum-sensitive recurrent ovarian cancer [1]. Dr Domenica Lorusso (San Raffaele Scientific Institute, Italy) presented the phase 3 MIT023 trial results which assessed the efficacy and safety of trabectedin in patients with BRCA-mutated or BRCAness phenotype recurrent epithelial ovarian cancer [2]. In total, 244 patients were randomised 1:1 to trabectedin or investigator’s choice chemotherapy. The primary endpoint was overall survival (OS). After a median follow-up of 18.8 ...


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