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Newly discovered neutrophils promote neuron survival, axon regeneration

Nature Immunology
Reuters Health - 30/10/2020 - A newly recognized subset of neutrophils promotes neuron survival and axon regeneration in the central nervous system (CNS), researchers report. "In previous studies of wound healing, subpopulations of monocytes have been implicated in repair," said Dr. Benjamin M. Segal of The Ohio State University Wexner Medical Center, in Columbus, and the University of Michigan, in Ann Arbor. "It is extremely interesting that a cell of the neutrophil lineage acts in that capacity within the central nervous system, rescuing dying neurons and stimulating new nerve fiber growth," he told Reuters Health by email. Immune-driven CNS axon regeneration following crushing injury to the murine optic nerve (a classic model) is enhanced by intraocular injection of zymosan, whose active ingredient is beta-1,3-glucan, which binds to the innate immune pattern recognition receptor dectin-1. The mediators that trigger neurorepair downstream of dectin-1 signal...

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