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Cardiorespiratory fitness protects against dementia

Presented By
Dr Edward Zamrini, Washington DC VA Medical Center, DC, USA
AAN 2022
In a large, prospective study, high cardiorespiratory fitness lowered the risk of developing Alzheimer’s disease (AD) and related disorders (ADRD). The association was inverse, independent, and graded: the highest-fit group had the lowest ADRD risk, the lowest-fit group the highest. Cardiorespiratory fitness is associated with favourable health outcomes, but the impact on the risk of incident AD/ADRD is unknown [1]. This relationship was examined in 649,605 military veterans in the Veterans Health Administration database who completed a standardised exercise treadmill test between 2000 and 2017 and did not have ADRD at that time [2]. Participants were aged between 30 and 95 years (average age: 61 years); 5.7% were women and 16.6% African Americans. Based on peak metabolic equivalents (METs) during the first exercise treadmill test, they were differentiated into 5 age-specific fitness categories: lowest-fit (n=132,634; METs=3.8), low-fit (n=129,49...

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